Journal of Innovations in Applied Pharmaceutical Science (JIAPS) https://saap.org.in/journals/index.php/jiaps <p><span style="color: #000000;">Journal of Innovations in Applied pharmaceutical Science (JIAPS) is an open access, quarterly, peer-reviewed multi-disciplinary journal; and will publish articles in various streams of pharmaceutical &amp; allied sciences. JIAPS publishes original research and review articles, Mini-reviews, Short communication, Case studies and editorial commentary and news, Opinions &amp; Perspectives and Book Reviews written at the invitation of the Editor in the fields of applied pharmaceutics</span></p> en-US <p>Copyright © Author(s) retain the copyright of this article.</p> info@saap.org.in (Support) info@saap.org.in (Tech Support) Mon, 26 Feb 2024 00:00:00 +0530 OJS 3.1.2.4 http://blogs.law.harvard.edu/tech/rss 60 Application of nanogel as a topical drug delivery vehicle for diclofenac sodium https://saap.org.in/journals/index.php/jiaps/article/view/576 <p>Diclofenac is an analgesic and belongs to the non steroidal and anti inflammatory drug [NSAIDS] that is widely used to tricot pain and inflammation. When used by the oral route, only about 50% of absorbed dose of diclofenac becomes systematically available due to first-pass metabolism. The objectives of the present investigation were the product quality and performance must be comparable to the innovator product in the order to ensure therapeutical equivalence. The present study is to formulate nanosize dispersion of diclofenac sodium by emulsion solvent diffusion method and incorporation of gelling agent to product nanogel. The formulation and characterized for particle size range from 100-400 nanometers. A drug name diclofenac sodium used in chronic diseases. FTIR spectrum it was concluded that the drug sample was in pure form. It was found that drug absorbance is 226 &amp; 276 nm but maximum absorbance was at 276nm. When solution is prepared in distilled water for quantitative evaluation purpose through the medium of evaluation of release in phosphate buffer PH 6.8. The graph absorbance Vs concentration was found to be linear in the concentration range of 424µg/ml at 276nm. The R2 of the calibration curve was found to be 0.999. Nanogel formation containing diclofenac sodium was successfully prepared and shows effective as was as better carrier for the topical preparation. The production of formulation also proceeds be better and cost effective comparision with oral dosage forms.</p> LakshmiSavithri S Copyright (c) 2024 https://saap.org.in/journals/index.php/jiaps/article/view/576 Tue, 16 Apr 2024 00:00:00 +0530 Polymeric nanoparticles for oral delivery of biopharmaceuticals: an overview https://saap.org.in/journals/index.php/jiaps/article/view/565 <p>Biopharmaceuticals, cutting-edge medications sourced from living organisms, embody the zenith of therapeutic progress driven by biotechnological breakthroughs. While oral drug delivery is convenient, it proves challenging for biopharmaceuticals due to the complex barriers in the gastrointestinal tract. Their delicate structure and susceptibility to degradation in the gut pose formidable obstacles. This scientific conundrum necessitates innovative solutions to ensure their effectiveness. Pseudomonas aeruginosa's Exotoxin A demonstrates the difficulty in traversing the intestinal epithelium, necessitating innovative strategies. Researchers utilize mucoadhesive, biodegradable polymers like alginate and chitosan to create nanoparticles. These nanoparticles form a protective gel in the stomach's acidic environment, enhancing drug stability and absorption. Chitosan and alginate collaborate in nanoparticle formulations, improving mucosal adhesion and prolonging drug retention. Introducing non-toxic Exotoxin A enhances trans-epithelial transport, validated by in vitro studies on Caco-2 cell monolayers and accumulation in the rat small intestine's lamina propria. Utilizing green fluorescent protein as a model within alginate-chitosan nanoparticles showcases their potential for oral drug delivery. Bacterial toxins play a crucial role in enhancing trans-epithelial transport, endorsing these nanoparticles. This fusion of biotechnology and polymer science offers a promising solution for biopharmaceutical oral delivery challenges, highlighting alginate-chitosan nanoparticles as versatile carriers for transformative drug delivery advancements.</p> Shanmugarathinam Alagarsamy, Subhasini Kandasamy, Ruckmani Kandasamy, Nandhamurugan Ramachandran, Gopikrishnan Muthurasu, Mukesh Kumar Venkatesan Copyright (c) 2024 https://creativecommons.org/licenses/by-nc/4.0 https://saap.org.in/journals/index.php/jiaps/article/view/565 Mon, 26 Feb 2024 00:00:00 +0530 Bioinspired methods for silver nanoparticle production: applications in biomedicine https://saap.org.in/journals/index.php/jiaps/article/view/567 <p>This review examines the green synthesis of silver nanoparticles using <em>Cassia auriculata&nbsp; </em>&nbsp;leaf and flower extracts. It outlines the extraction process, properties, and potential applications, with visual confirmation and scientific validation through UV-Visible spectroscopy, XRD, SEM, and Scherrer's formula. The AgNPs synthesized displayed unique Surface Plasmon Resonance, an optical property that enables them to produce specific colors. The further application of these nanoparticles was examined in formulating a bactericidal cold cream, which showed significant antibacterial potency against common pathogenic bacteria. The characterization of these nanoparticles spanned various technique usages, including UV-visible spectrometer, transmission electron microscope (TEM), energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) analysis, Atomic force microscopy and high-resolution transmission electron microscopy are two techniques used for analyzing complex materials.The review confirms the potential of biosynthesized silver nanoparticles from <em>Cassia auriculata&nbsp; </em>&nbsp;in antibacterial formulations, emphasizing the need for further research to optimize eco-friendly processes and unlock novel applications, particularly in biomedicine.</p> Dhachinamoorthi D, Pavan Kumar P, Tharun Sai Ch, Bhavana Priya G, Gnana Prasuna V, Ratna Kumari B, Sasidhar B Copyright (c) 2024 https://creativecommons.org/licenses/by-nc/4.0 https://saap.org.in/journals/index.php/jiaps/article/view/567 Sat, 02 Mar 2024 00:00:00 +0530 Lipid-Based Nanoparticles https://saap.org.in/journals/index.php/jiaps/article/view/573 <p>Lipid-based nanoparticles (LNPs) are nano-sized particles composed of lipids, which are natural or synthetic molecules. It comprises of phospholipid bilayer in its structure. The unique properties of lipids such as biocompatibility and versatility, have spurred the development of various lipid based nano formulations. It has different types of lipid-based nanoparticles including liposomes, lipid nanoemulsions, solid lipid nanoparticles, nanostructured lipid carriers, and lipid-polymer hybrid nanoparticles. This review focused on the preparation methods and applications of LNPs. The various production techniques, such as injection, sonication, microfluidization, homogenization, microemulsion, nanoprecipitation, and evaporation methods were discussed. Among the various nanomaterials, lipid-based nanoparticles (LNPs) have shown remarkable pharmacological performance and therapeutic outcomes. Additionally, these carriers can enhance the drug distribution, bioavailability, encapsulation efficiency, drug loading capacity, pharmacokinetic properties and thus, results in minimizing the adverse side effects. The LNPs as promising carriers for targeted drug delivery in gene therapy and cancer therapy.</p> Sindhu Gillella Copyright (c) 2024 https://saap.org.in/journals/index.php/jiaps/article/view/573 Sun, 07 Apr 2024 00:00:00 +0530 Polymeric nanoparticles – a review https://saap.org.in/journals/index.php/jiaps/article/view/575 <p>Polymeric nanoparticles have emerged as versatile and promising platforms in the field of nanotechnology, offering unique properties and functionalities for various applications. These nanoparticles, typically ranging from 1 to 1000 nanometers in size, are composed of biocompatible or biodegradable polymers, offering controlled drug delivery, imaging capabilities, and targeted therapy. This abstract provides an overview of the synthesis methods, characterization techniques, and applications of polymeric nanoparticles in drug delivery, gene therapy, diagnostics, and imaging. Various polymeric materials, including synthetic and natural polymers, are explored for their suitability in nanoparticle formulations. The choice of polymers influences crucial properties such as biocompatibility, biodegradability, and controlled drug release kinetics, enhancing the therapeutic efficacy and reducing side effects. The ability to encapsulate a diverse range of payloads, including hydrophobic and hydrophilic compounds, makes polymeric nanoparticles highly adaptable for different applications.</p> Sindhu Gillella, Divyanjali M, Rishitha S, Amzad SK, UshaKiran Reddy T, Girish C, Apparao CH Copyright (c) 2024 https://saap.org.in/journals/index.php/jiaps/article/view/575 Fri, 12 Apr 2024 00:00:00 +0530