Journal of Innovations in Applied Pharmaceutical Science (JIAPS)

Isolation and characterization of Samanea SamanFruit Gum: Natural strong binding agent for Controlled drug delivery system

Asha Parveen, Surendra Pratap Singh, Santosh Kumar R, Pavani M, B.V. Raju M — Fri, 01 Sep 2023 00:00:00 +0530

Controlled drug delivery system (CDDS) is majorly used oral conventional dosage forms. They regulate the drug level in your body for specific time period. This leads to precise medication levels even after taking it once, preventing from taking multiple doses throughout the day. CDDS increases patient compliance and decreases toxicity due to dose dumping in body. In recent era,the number of synthetic and semi synthetic polymers availability in market has increased in order to prepare strong binders for CDDS but they are having many disadvantages such as costly, toxic, there side effects and poor patient compliance along with environmental hazard during synthesis. Because of these side effects we are choosing natural gums such as gum obtained from fruits of Samanea saman which are eco- friendly as well as low cost and strong binder. In the following studies effort were made and depicted of Samanea saman gum extraction from the Samanea saman fruits and the gum is evaluated for their various physical characteristics. Samanea saman possesses various additional properties like non carcinogenicity, broad pH tolerance, high viscosity and biocompatibility. This extract is also used by food and pharmaceutical industries as thickening agent, gelling agent, stabilizer, this fruit constitutes about 65% of polysaccharide in the fruit components.

A critical analysis of the vesicular drug delivery system: recent advancements and prospects for the future

Teja Kumar Reddy Konatham , Sahithi Alapati — Sat, 09 Sep 2023 00:00:00 +0530

Vesicular system drug design has revitalised the efficacy of previous medications by effectively regulating and sustaining their therapeutic action. The objective of this study is to evaluate the feasibility of utilizing pharmaceutical interventions to target novel vesicular drug delivery systems. The objective of innovative medication administration is to minimize adverse effects while ensuring drug efficacy at a predetermined or reasonably consistent level within the body. A novel drug delivery approach is characterized by the controlled release of medication at a predetermined rate, which is determined based on factors such as therapeutic requirements, pharmacological properties, drug characteristics, physiological condition of the organism, and other relevant considerations. At present, there is a lack of medication delivery technologies that effectively achieve the aforementioned objectives while minimizing adverse effects. The utilization of vesicular systems in drug delivery has brought about changes in the understanding and application of diagnosis and therapy across different domains within the biomedical field. The vesicular drug delivery system (VDDS) serves as a means to address the disparity between the theoretical ideal and the presently accessible innovative drug delivery systems, accomplishing this by enclosing active moieties within vesicular structures. Various vesicular drug delivery systems, such as liposomes, niosomes, transferases, pharmacosomes, colloidosomes, herbosomes, sphinosomes, among others, have been developed. This review primarily focuses on the examination of various pharmacological targets, both lipiodal and nonlipoidal, within vesicular systems. Liposomes and niosomes represent innovative drug delivery systems.

Catalyzing Drug Safety: Harnessing IoT and Block chain Technology and its Synergy in Pharmacovigilance

John Praveen — Sun, 17 Sep 2023 09:26:06 +0530

The convergence of Internet of Things (IoT) and blockchain technologies is catalysing a paradigm shift in the field of pharmacovigilance. This article provides an overview of the application of IoT and blockchain in pharmacovigilance, highlighting their transformative potential in enhancing patient safety and drug efficacy monitoring. IoT devices enable real-time data collection, enabling prompt identification of adverse events, while blockchain ensures data integrity and security. Together, they create a robust ecosystem for pharmacovigilance, allowing for transparent reporting, streamlined adverse event management, and proactive measures to safeguard public health. This paper explores key use cases, benefits, challenges, and prospects of this innovative approach, emphasizing its pivotal role in shaping the future of drug safety and regulatory compliance in the pharmaceutical industry.