Journal of Innovations in Applied Pharmaceutical Science (JIAPS) 2021-12-31T00:00:00+0530 Support Open Journal Systems <p><span style="color: #000000;">Journal of Innovations in Applied pharmaceutical Science (JIAPS) is an open access, quarterly, peer-reviewed multi-disciplinary journal; and will publish articles in various streams of pharmaceutical &amp; allied sciences. JIAPS publishes original research and review articles, Mini-reviews, Short communication, Case studies and editorial commentary and news, Opinions &amp; Perspectives and Book Reviews written at the invitation of the Editor in the fields of applied pharmaceutics</span></p> Formulation and Evaluation of Ficus Benghalensis Emulgel for its Anti- Rheumatoid Arthritis Effect 2021-09-30T12:50:26+0530 Sonali Mohd. Aqil Siddiqui Amresh Gupta Arpita Singh Nitish Kumar <p>The current study focuses on the development and characterization of ficus benghalensis powdered aerial roots emulgel to avoid the first-pass effect and strengthen bioavailability while reducing dosage intervals and dose-related deleterious reactions. three formulations with the same concentration and different polymers were formulated. Ethanolic and petroleum ether extract of dried aerial roots of ficus benghalensis were prepared by using different gelling agents like&nbsp; Carbopol 934, Carbopol 940, and Xanthane gum was formulated. The prepared formulations were evaluated for their qualitative as well as quantitative tests, physical appearance, pH, viscosity, spreadability, consistency, homogeneity, moisture loss, and finally in vitro anti-arthritic activity. Depending on the outcomes, it was observed that to all the formulation, F1 formulation containing Carbopol 940 with 4.6% moisture loss, 3780.3±5.0 viscosity and 6.1±0.1 PH and 43.7±1.53 spreadability shows better activity then all the other. Herbal emulgel of ethanolic extract of dried aerial roots of ficus benghalensis line, when compared with diclofenac emulgel, confirms the anti-arthritic activity through invitro release method.</p> 2021-09-29T00:00:00+0530 Copyright (c) 2021 Sonali Formulation and optimization of synthetic polymer based herbal emulgel for anti-microbial activity 2021-09-30T12:52:11+0530 Namrata Patel Nitish Kumar Arpita Singh Amresh Gupta <p>The aim of the present research was to develop and evaluate the anti-microbial emulgel by using three different types of synthetic polymers. The active moiety selected for the formulation was the seeds of Carica papaya fruit. The formulation was developed by performing the extraction process; Soxhlet extraction with ethanol and water. The seeds of Carica papaya are reported to have anti-microbial properties. The skin-friendly i.e., the topical formulation was selected for development. Emulgel was prepared by incorporating different polymers and then evaluating each of them for best results. Basic evaluation parameters such as organoleptic parameters, viscosity, consistency, pH, homogeneity have been done, which demonstrate the results as per the reference and standard articles. Along with that, qualitative and quantitative tests of Carica seeds have also been performed, which indicates that the selected plant material is safe for usage. Finally, the most imp test, the anti-microbial test has been performed for determining the efficacy of prepared emulgel. Hence, it can be concluded that the prepared emulgel is safe and best for topical use as an anti-microbial.&nbsp;</p> 2021-09-29T00:00:00+0530 Copyright (c) 2021 Namrata Patel A review study on the anti depressant and anti oxidant activities of pisidum guajava and allium sativum 2021-09-20T16:59:43+0530 Anil Kumar Y Lalitha Lavanya S. K Ravi Kumar Konda Prathyusha A <p>When stress affects the body it interferes with physiological functions of the body and other normal functions such as physical and emotional behaviors of the individual and this is associated with the cause of depression, anxiety mental disorders. Here comes the cause of irrational responses of the body system. The different forms of irrational response are the symptoms for depression. Severe depression with significant effect on day to day life is considered as disability. There are so many synthetic medicines that are used to treat depressions they are playing a prominent role in this civilized world with so many adverse effects, in the other hand natural/ herbal medicines are also playing a crucial role with minimum to zero side effects.One of the main causes of depression is oxidative stress, which is a type of imbalance between the production of reactive oxygen species and the anti-oxidant defensive system.</p> 2021-09-20T00:00:00+0530 Copyright (c) 2021 A review on vaccines – benefits and risks 2021-10-04T16:54:56+0530 Akhil Susmith P Soha Sanobar Prathyusha Vadluri Bhavya Sri Pratap Kabya <p>The article outlines the benefits and risks of vaccines. Vaccine safety and myths and misinformation, the general review of the importance of the vaccines. Steps involved in the Development of Vaccines and also illustrates the immunization importance and its disadvantages. Administration of vaccines in different age groups. Classification of different available vaccines in the health market. Also stating the possible adverse drug reactions / potential side effects of the vaccines and their monitoring and management of adrs. We concluded that Vaccine acceptance must be widespread in order to provide herd immunity so that individuals who cannot be directly protected by vaccination are protected by communal immunity. The danger is quite low, and the advantages of vaccinations usually outweigh it.</p> 2021-09-30T00:00:00+0530 Copyright (c) 2021 Akhil Susmith P Technical Documentation Requirements for Medical Devices Approval in European Union and a Detailed Emphasis on Air-way Products 2021-10-21T13:31:31+0530 Shanmukhi Kondrath Ramaiah Maddi <p>The technical documentation to be drawn up by the maker ought to be introduced in an unmistakable, coordinated, promptly accessible, and unambiguous way. It will remember for specific the components recorded as per Annex II of EU MDR 2017/745. The Air-Way is the way that air follows to get into and out of the lungs. There are a few kinds of Air-way devices are there on the lookout. New items will conceivably further develop patient prosperity altogether however will require sensible administrative control to boost the advantages. The orderly methodology is planned on a central theoretical level that underlies the substantial necessities that could be changed during the years to follow. The current article gives an itemized accentuation on Air-way items and their tech documentation necessities.</p> 2021-10-18T00:00:00+0530 Copyright (c) 2021 Shanmukhi Kondrathi and Ramaiah Maddi Humeral shaft fracture associated with radial nerve palsy -a case report 2021-10-28T22:27:41+0530 Rishitha M Akasha Sindhu M <p>Radial nerve palsy was induced by radial nerve compression, which was often caused by humerus bone fracture. This leads to pain, weakness, or loss of function mostly in the wrist, hand, and fingers. We reported a case of a 24-year-old male patient with complaints of swelling of the right-hand wrist joint and pain during extension and flexion while moving. He had a three-month history of mild displaced humeral shaft fracture from a traffic accident and an intramedullary Ender nailing was performed. He now has been admitted with swelling in his right wrist joint and pain while moving his hand. The case was diagnosed as Radial nerve palsy. Surgery was performed, the proximal and distal ends of the radial nerve were separated at the humeral bone's surface. The radial nerve stumps were enough long to be sutured. Our one-month follow-up shows no complications. The majority cases of radial nerve palsy will resolve within a few weeks after surgery, as our patient did, and the most prominent is patient education.</p> 2021-10-28T00:00:00+0530 Copyright (c) 2021 Case report on ischemic stroke 2021-11-22T09:38:40+0530 Chandini Kosuru Sharmila T Usha Sri Kanumula Tanuja Lakshmi CH Madhurismith V <p>This case report is mainly about the ISCHEMIC STROKE. In this the arteries become narrow, and fat get deposited (plaque) know as Atherosclerosis which is due to blockage of blood &amp; oxygen supply to part of the brain. It affects more than 795,000 people in the United States.&nbsp; Basing on clinical features, histopathological it has to diagnose and treated immediately to prevent the paralyzing life of people.</p> 2021-11-15T00:00:00+0530 Copyright (c) 2021