Antioxidant properties of 5 herbal plants based of pharmacophore modelling

Sam Ezekiel Radhakrishnan; Mohammad Farhan  Ariffeen Rosli; Ardy Mursyid Romli; Tiara Nales Nyawai; Razip Asaruddin

Sam Ezekiel Radhakrishnan Faculty of Resource Science and Technology, Universiti Malaysia Sarawak (UNIMAS), Malaysia.
Mohammad Farhan Ariffeen Rosli Faculty of Resource Science and Technology, Universiti Malaysia Sarawak (UNIMAS), Malaysia
Ardy Mursyid Romli Faculty of Resource Science and Technology, Universiti Malaysia Sarawak (UNIMAS), Malaysia.
Tiara Nales Nyawai Faculty of Resource Science and Technology, Universiti Malaysia Sarawak (UNIMAS), Malaysia.
Razip Asaruddin Faculty of Resource Science and Technology, Universiti Malaysia Sarawak (UNIMAS), Malaysia.

Abstract

Malaysian medicinal plants are known to exert therapeutic effects.We have evaluated some species namely Moringa oleifera (M. Oleifera), Clinacanthus nutans (C. Nutans), Rhodomyrtus tomentosa (R. tomentosa), Arctium lappa(A. lappa) and Sonneratia alba (S. alba) for their antioxidant properties assisted by using pharmacophore modelling approach. Major compounds were displayed from each plantnamely; 3-caffeoylquinic, benzylglucosinolate, kaempferol, leucodelphinidin and quercetin from M.oleifera, adenosine, arctigenin, arctiin, and solasoninefrom A. lappa, 2-cis-entadamine A, phaeophytin, clinamides B, isovitexin, and vitexinfrom C .nutans, 5-hydroxymethylfurfural, alphitolic acid, betulin, methyl gallate, oleanolic acid from S. alba and lupeol, rhodomyrtone A, rhodomyrtone B, rhodomyrtone C and rhodomyrtone D from R. tomentosa.

Keywords: Pharmacophore Modelling, Antioxidant properties, Moringaoleifera, Clinacanthusnutans, Rhodomyrtus tomentosa, Arctium lappa, Sonneratia alba, and Ligand-Based Pharmacophore

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