Journal of Case Studies and Case Reports 2023-11-17T23:24:16+0530 Editor in Chief Open Journal Systems <p>Journal of Case Studies and Case Reports (<em>Jour Cas Stu Cas Rep</em>) is a&nbsp;double-blind peer-reviewed Quarterly open access international journal&nbsp;dedicated to the interesting cases and case series of all medical areas.</p> A Nortriptyline toxicity induced by interaction with Terbinafine 2023-11-17T23:24:16+0530 Abigail Swager Gillian Balbir-Singh <p>Tricyclic antidepressants are widely used and associated with neurological compromise at supratherapeutic doses. Cases of toxicity from tricyclic antidepressants induced by systemic antifungal agents have been infrequently documented in the literature, and postulated to occur as a consequence of imbibition of the CYP2D6 pathway. Caution is recommended with regard to concurrent prescriptions of these medications, however this interaction does not appear to be widely appreciated in clinical practice. We present a case report of Nortriptyline toxicity from the interaction of Terbinafine. Given the frequent usage of both classes of medications in primary and tertiary care, increased awareness of this interaction is essential in preventing morbidity, and in early recognition and management of toxicity when it occurs.</p> 2023-11-17T22:58:18+0530 Copyright (c) 2023 Abigail Swager, Gillian Balbir-Singh