A review on phytosomes as innovative delivery systems for phytochemicals

  • Anil Kumar Tallam Department of pharmacy,Shri Venkateshwara University,Rajabpur, NH-24, Venkateshwara Nagar, Gajraula, Uttar Pradesh 244236
  • Alapati Sahithi Assistant Professor, Department of Pharmaceutical Analysis,Nalla Narasimha Reddy Education Society's Group of Institutions,Narapally, Ghatkesar Mandal, Korremula Rd, Hyderabad, Telangana 500088
  • Mohana Vamsi Nuli Associate Professor,Raghavendra Institute of Pharmaceutical Education and ResearchK.R. Palli Cross, Dist Anantapuramu, Chiyyedu, Andhra Pradesh 515721

Abstract

Nowadays, medicinal herbs and their phytochemicals have emerged as great therapeutic options for many disorders. However, poor bioavailability and selectivity might limit their clinical application. Therefore, bioavailability is considered a notable challenge to improving bio-efficacy in transporting dietary phytochemicals. Different methods have been proposed for generating effective carrier systems to enhance the bioavailability of Phytochemicals. Among them, nano-vesicles have been introduced as promising candidates for the delivery of insoluble phytochemicals. Due to the easy preparation of the bilayer vesicles and their adaptability, they have been widely used and approved by the scientific literature. The first part of the review is focused on introducing pyrosomes technology as well as its applications, with emphasis on principles of formulations and characterization. The second part provides a wide overview of the biological activities of commercial and non-commercial pyrosomes, divided by systems and related pathologies. These results confirm the greater effectiveness of pyrosomes, both in terms of biological activity or reduced dosage, high-lighting curcumin, and Silymarin as the most formulated compounds. Finally, we describe the promising clinical and experimental findings regarding the applications of pyrosomes. The conclusion of this study encourages the researchers to transfer their knowledge from laboratories to the market, for further development of these products.

Keywords: phytochemical, Nano medicine, pyrosomes, delivery, vesicle, disease

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References

1. LuM,QiuQ,LuoX,etal.Phyto-phospholipidcomplexes (phytosomes): anovelstrategy to improve the bioavailability of active constituents. Asian J Pharm Sci.2019;14(3):265–274.doi:10.1016/j.ajps.2018.05.011
2. RaeiszadehM,Esmaeili-TarziM,Bahrampour-JuybariK,etal.Evaluationtheeffectof Myrtus-communis L. extract on several underlying mechanisms involved in woundhealing: anin vitrostudy.SAfrjBot.2018;118:144–150.doi:10.1016/j.sajb.2018.07.006
3. Singh, A., 2022. Role of microbial metabolites in cardiovascular and human health. In Micro-biome, Immunity, Digestive Health and Nutrition (pp. 137-148). Academic Press.
4. PoursalehiHR, FekriMS,FarFS, etal. Earlyand-latepreventiveeffectofNigellasativa on the bleomycin-induced pulmonary fibrosis in rats: an experimental study.Avicenna J Phy-tomed.2018;8(3):263.
5. Oloumi MM, Vosough D, Derakhshanfar A, et al. The healing potential of Plantagolanceo-lataointmentoncollagenase-inducedtendinitis inburros(Equusasinus). JEquineVet-Sci.2011;31(8):470–474.doi:10.1016/j.jevs.2011.03.014
6. Samareh-FekriM,PoursalehiHR, Mande-garyA,etal. Theeffectofmethanolextractof-fennelonbleomycin-inducedpulmonaryfibrosisin-rats.JKermanUnivMedicalSci.2015;22(5):470–483.
7. BhisJJ,BhusnureOG,JagtapSR,GholveSB,WaleRR.Phyto somes: anoveldrugdeliveryforherbalex-tracts.JDrugDelivTher.2019;9(3–s):924–930.
8. Teng Z, Yuan C, Zhang F, et al. Intestinal absorption and firstpass metabolism ofpolyphenol compounds in rat and their transport dynamics in Caco-2 cells. PLoS One. 2012;7(1):e29647.doi:10.1371/journal.pone.0029647
9. ManachC,ScalbertA,MorandC,RémésyC,JiménezL.Polyphenols:foodsourcesandbioavailability.AmJ ClinNutr.2004;79(5):727–747.
10. BhattacharyaS. Phytosomes: thenewtechnologyforenhancementofbioavailabilityofbotanicalsandnutraceuticals. Int J Health Res.2009; 2(3):225–232. doi:10.4314/ijhr.v2i3.47905
11. KiddP,HeadK.Areviewofthebioavailabilityandclinicalefficacyofmilkthistlephytosome: a sily-bin-phosphatidylcholine complex (Siliphos). Altern Med Rev.2005;10(3):193–203.
12. Konatham Teja Kumar Reddy, & M. Akiful Haque. (2022). Develop and validate a highly sensitive method for the estimation of Mol-nupiravir in rat plasma by high-performance liquid chromatography-tandem mass spectros-copy and its application to pharmacokinetic studies. Journal of Pharmaceutical Negative Results, 28–34. https://doi.org/10.47750/pnr.2022.13.S01.0
13. Singh, A., Kumar, A. and Kalaiselvi, P., 2018. Aegeline, targets LOX1, the receptor for oxi-dized LDL to mitigate hypercholesterolemia: a new perspective in its anti-atherosclerotic ac-tion. Free Radical Biology and Medicine, 128, p.S41.
14. Konatham Teja Kumar Reddy, Penke Vijaya Babu, Rajinikanth Sagapola, & Peta Sudhakar. (2022). A REVIEW OF ARTIFICIAL INTELLI-GENCE IN TREATMENT OF COVID-19. Jour-nal of Pharmaceutical Negative Results, 254–264. https://doi.org/10.47750/pnr.2022.13.S01.31
15. Konatham Teja Kumar Reddy, Kumaraswamy Gandla, Penke Vijaya Babu, M Vinay Kumar Chakravarthy, Pavuluri Chandrasekhar, & Ra-jinikanth Sagapola. (2022). A CRITICAL RE-VIEW ON BIOANALYTICAL METHOD DE-VELOPMENT AND VALIDATION OF FEW ONCOLOGY DRUGS BY USING LC-MS-MS. Journal of Pharmaceutical Negative Results, 16–27. https://doi.org/10.47750/pnr.2022.13.S01.03
16. Reddy, K. T. K., & Haque, M. A. (2022). Bioana-lytical method development and validation of atrasentan in human plasma using verapamil as internal standard by liquid chromatography coupled with tandem mass spectrometry. International Journal of Health Sciences, 6(S8), 625–638. https://doi.org/10.53730/ijhs.v6nS8.10470
17. Singh, A., Srinivasan, A.K., Chakrapani, L.N. and Kalaiselvi, P., 2019. LOX-1, the common therapeutic target in hypercholesterolemia: a new perspective of antiatherosclerotic action of aegeline. Oxidative medicine and cellular longevity, 2019.
18. Konatham Teja Kumar Reddy et.al High Per-formance Liquid Chromatography for The Si-multaneous Estimation of Anti-Ulcer Drugs in Pharmaceutical Dosage Form, journal of Posi-tive School Psychology, Vol. 6, No. 9, 4524-452
19. Reddy KTK, Haque MA. Development and Validation of a High Throughput Lc-Ms/MS Method for Quantitation of Ipilimumab in Human Plasma. International Journal of Phar-maceutical Quality Assurance. 2022;13(3):303-307
20. Singh, A., 2022. Hyperlipidemia in cardiovas-cular health and digestion. In Nutrition and Functional Foods in Boosting Digestion, Me-tabolism and Immune Health (pp. 141-150). Academic Press.
21. Teja Kumar Reddy Konatham, M. Anuradha (2020), a stability indicating method develop-ment and validation of Telmisartan and Nifedipine in pure form using RP-HPLC. In-ternational Journal of Pharmaceutical, Biologi-cal and Chemical Sciences, 9(3): 36-44
22. Teja Kumar Reddy Konatham, Satyanarayana Reddy K., Anuradha Manipogo, a Review on viruses that originated from china; Sars, mers and covid-19 World Journal of Pharmaceutical Research, Vol 9, Issue 5, 2020, 2010-2015.
23. Teja Kumar Reddy Konatham et al, A System-atic Review on Method Development and Validation of Few Antiviral Drugs by Using RP-HPLC. Ijppr.Human, 2021; Vol. 21 (3): 651-661.
24. Konatham Teja Kumar Reddy and Kumaras-wamy Gandla. Novel Vesicular Drug Delivery Systems Proniosomes. Pharm Res 2022, 6(3): 000272.
25. Yelampalli SR, Gandla K, Reddy KT, Ibrahim AE, El Deeb S. Determination of Sodium, Po-tassium, and Magnesium as Sulfate Salts in Oral Preparations Using Ion Chromatography and Conductivity Detection. Separations. 2023 Feb 1;10(2):99.
26. Deepti, A., & Sahithi, A. (2022). A sensitive bio-analytical method development and validation of afatinib in human plasma by LC-ESI-MS/MS. International Journal of Health Sciences, 6(S5), 1736– 1384. https://doi.org/10.53730/ijhs.v6nS5.9522
27. Singh, A., Gowtham, S., Chakrapani, L.N., Ashokkumar, S., Kumar, S.K., Prema, V., Bha-vani, R.D., Mohan, T. and Sathyamoorthy, Y.K., 2018. Aegeline vs Statin in the treatment of Hypercholesterolemia: A comprehensive study in rat model of liver steatosis. Functional Foods in Health and Disease, 8(1), pp.1-16.
28. Kumar, K. P., Marathakam, A., Patnaik, S., Kumar, S., Sahithi, A., Priya, D. K. S., & Dogra, P. (2022). An insight of development and vali-dation of bioanalytical method in the reference of anticancer drugs by using LC-MS/MS. International Journal of Health Sciences, 6(S3), 6349–6361. https://doi.org/10.53730/ijhs.v6nS3.7454
29. Alapati Sahithi, B.Parijatha, D.Santhoshi Priya, Krishna Mohan Chinnala, Method Develop-ment and validation of Metformin by using RP-HPLC, World Journal of Pharmaceutical Research, 2277-7105, 6(8); August,2017
30. Sahithi et al, Stability indicating reverse-phase high-performance liquid chromatography method development and validation of Imatinib, International Journal of Research and Analytical Reviews, Vol 7, Issue 3, 322-333, September 2020. DOI: 10.20959/wjpr20178-9069
Published
19/02/2023
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How to Cite
Tallam, A. K., A. Sahithi, and M. V. Nuli. “A Review on Phytosomes As Innovative Delivery Systems for Phytochemicals”. International Journal of Pharmacognosy and Chemistry, Vol. 4, no. 1, Feb. 2023, pp. 1-8, doi:10.46796/ijpc.v4i1.416.
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Review Article