International Journal of Indigenous Herbs and Drugs

An updated review on niosomes: a promising drug carrier

Ramesh Kandpal — 2023-11-03

Nowadays, advancement in nanocarrier technology gain interest of researchers because it offered various advantages in term of safety and efficacy like enhanced delivery of therapeutics with diverse pharmacological effects, featuring improved targeting capabilities and minimized adverse effects over other carrier systems. Similarly, Niosomes proved as a promising and novel drug carrier. Niosomes are vesicular drug carrier approach which provides controlled and targeted drug delivery. It consist non-ionic surfactants, cholesterol or its derivatives and charged molecules and can be unilamellar, oligolamellar or multilamellar. Their distinctive attributes include the ability to encapsulate both hydrophilic and lipophilic components. This review article illustrates all the basic details of niosomes like structure of niosomes, types of niosomes, its merits and demerits, routes of administration, methods of preparation, factors affecting their formation, evaluation criteria for niosomes as well as their applications and existing marketed formulations.

Buccal Patches: A Comprehensive review

Shivani Prajapati — 2023-11-11

The buccal mucosa is one of the administration sites that might provide an alternative for peroral administration. The successful delivery of drugs across the oral mucosa represents a continuing challenge, as well as a great opportunity. Buccal delivery, has progressed far beyond the use of traditional dosage forms with novel approaches emerging continuously. Buccal drug delivery system in which drug enters directly in systemic circulation thereby by passing the first pass effect. This is painless and without discomfort, precise dosage form and facilitates ease of removal without significant associated pain. Moreover it shows better stability, patient compliance; uniform and sustained drug release and above all easy and cheap methods of preparation which can be done with various commonly available biocompatible polymers. The buccal route has been researched for a wide variety of drugs and has gained significant attention and momentum since it offers remarkable advantages. Over past few decades, buccal route for systemic drug delivery using mucoadhesive polymers to significantly improve the performance of many drugs has been of profound interest. Present article deals with the different aspect of the buccal patches.

A systematic review on wound healing

Aftab Quraishi MD — 2023-11-12

The body's initial line of defence, the skin protects the inside organs from heat, chemical, and mechanical harm. It has a highly developed immune system that protects the body from harmful illnesses. The body's natural response to tissue damage is wound healing. But wound healing is a complicated process that involves a wide range of cell types, cytokines, mediators, and the vascular system interacting with one another. It is a complex, strictly controlled process that is essential to retaining all other skin functions in addition to the skin's barrier function. Numerous factors, both modifiable and non-modifiable, can impact this process. In order to successfully restore the damaged tissue, wound healing is a dynamic process supported by a variety of cellular processes, including as homeostasis, inflammation, proliferation, and remodelling. These activities must be properly integrated with one another. When there is damage to the skin, bacteria can swiftly infiltrate the tissues behind the skin, leading to life-threatening infections and chronic wounds. Natural phytomedicines with significant pharmacological qualities have been used extensively and successfully to treat wounds and prevent infections. Phytotherapy has been used for millennia to effectively cure skin wounds and delay the formation of infections. This study focuses on cutaneous wound healing and highlights the classical wound healing phases because wound healing occurs in many regions of the human body. Changes in any one of these stages may encourage the development of chronic wounds and hinder their healing. Numerous plants have been shown to aid in wound healing through a variety of processes.