An updated review on niosomes: a promising drug carrier
Nowadays, advancement in nanocarrier technology gain interest of researchers because it offered various advantages in term of safety and efficacy like enhanced delivery of therapeutics with diverse pharmacological effects, featuring improved targeting capabilities and minimized adverse effects over other carrier systems. Similarly, Niosomes proved as a promising and novel drug carrier. Niosomes are vesicular drug carrier approach which provides controlled and targeted drug delivery. It consist non-ionic surfactants, cholesterol or its derivatives and charged molecules and can be unilamellar, oligolamellar or multilamellar. Their distinctive attributes include the ability to encapsulate both hydrophilic and lipophilic components. This review article illustrates all the basic details of niosomes like structure of niosomes, types of niosomes, its merits and demerits, routes of administration, methods of preparation, factors affecting their formation, evaluation criteria for niosomes as well as their applications and existing marketed formulations.
2. Ugochukwu AE, Nnedimkpa OJ, Rita NO. Preparation and characterization of Tolterodine tartrate proniosomes, Universal Journal of Pharmaceutical Research 2017; 2(2): 1-3.
3. Singh S. Niosomes: a role in targeted drug delivery system. Int J Pharm Sci Res. 2013;4:550–557.
4. Nwobodo NN, Adamude FA, Dingwoke EJ, Ubhenin A. Formulation and evaluation of elastic liposomes of decitabine prepared by rotary evaporation method. Universal Journal of Pharmaceutical Research 2019; 4(3):1-5.
5. Barel A, Paye M, Maibach HI. Handbook of Cosmetic Science and Technology. New York, NY, USA: Marcel Dekker Inc.; 2001.
6. Chioma ED. Formulation and evaluation of etodolac niosomes by modified ether injection technique. Universal Journal of Pharmaceutical Research 2016; 1(1): 1-4.
7. A. K. Verma and J. C. Bindal, “A vital role of niosomes on controlled and novel drug delivery,” Indian Journal of Novel Drug Delivery, vol. 3, pp. 238–246, 2011.
Barel A, Paye M, Maibach HI. Handbook of Cosmetic Science and Technology. New York, NY, USA: Marcel Dekker Inc.; 2001.
8. John DF, Yunus AA, Chigbo UJ, Paul US, Ikenna E. Tolnaftate loaded liposomes-design, and in-vitro evaluation. Universal Journal of Pharmaceutical Research 2016; 1(2): 29-31.
9. S. Verma, S. K. Singh, N. Syan, P. Mathur, and V. Valecha, “Nanoparticle vesicular systems: a versatile tool for drug delivery,” Journal of Chemical and Pharmaceutical Research, vol. 2, no. 2, pp. 496–509, 2010.
10. ALGIN YAPAR E, ESENTÜRK İ, ŞAHİNER A, HALAT E, KARA BA, BALA R, SINDHU RK. Cosmetotextiles and evaluation of their performance. Universal Journal of Pharmaceutical Research 2021; 6(3):64-67.
11. A. Budhiraja and G. Dhingra, “Development and characterization of a novel antiacne niosomal gel of rosmarinic acid,” Drug Delivery, vol. 22, no. 6, pp. 723–730, 2015.
12. Elsaied EH, Dawaba HM, Ibrahim EA, Afouna MI. Investigation of proniosomes gel as a promising carrier for transdermal delivery of Glimepiride. Universal Journal of Pharmaceutical Research 2016; 1(2): 1-10.
13. S. Bhaskaran and P. K. Lakshmi, “Comparative evaluation of niosome formulations prepared by different techniques,” Acta Pharmaceutica Sciencia, vol. 51, no. 1, pp. 27–32, 2009.
14. Elsaied EH, Dawaba HM, Ibrahim ESA, Afouna MI. Effect of pegylated edge activator on Span 60 based nanovesicles: comparison between Myrj 52 and Myrj 59. Universal Journal of Pharmaceutical Research 2019;4(4):1-8.
15. A. Rogerson, J. Cummings, N. Willmott, and A. T. Florence, “The distribution of doxorubicin in mice following administration in niosomes,” Journal of Pharmacy and Pharmacology, vol. 40, no. 5, pp. 337–342, 1988.
16. Chauhan N, Kumar K, Pant NC. An updated review on transfersomes: a novel vesicular system for transdermal drug delivery. Universal Journal of Pharmaceutical Research 2017; 2(4): 42-45.
17. A. Marwa, S. Omaima, E. L. G. Hanaa, and A.-S. Mohammed, “Preparation and in-vitro evaluation of diclofenac sodium niosomal formulations,” International Journal of Pharmaceutical Sciences and Research, vol. 4, no. 5, pp. 1757–1765, 2013.
18. Anwar W, Dawaba HM, Afouna MI, Samy AM.Screening study for formulation variables in preparation and characterization of candesartan cilexetil loaded nanostructured lipid carriers. Universal Journal of Pharmaceutical Research 2019; 4(6):8-19.
19. Gayatri Devi S, Venkatesh P, Udupa N. Niosomal sumatriptan succinate for nasal organization. Int J Pharm Sci 2000;62:479-81.
20. Ojha A, Madhav NVS, Tyagi S, Basnet V, Parveen H. An exhaustive statistic on current mucoadhesive intravaginal drug delivery methodologies. Universal Journal of Pharmaceutical Research. 2017; 2(6): 76-84.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright © Author(s) retain the copyright of this article.