Indigenous plants as Oral Herbal Contraceptive: an Updated Review

  • Durga Priya Department of Pharmacology Al-AmeenCollege of Pharmacy Bangalore
  • Manjula GS Department of Pharmacology Al-AmeenCollege of Pharmacy Bangalore
  • Swati Mittal Department of Pharmacology Al-AmeenCollege of Pharmacy Bangalore
  • Sowmya Shree Department of Pharmacology Al-Ameen College of Pharmacy Bangalore
  • Mohammad Shaik Sahil Department of Pharmacology Al-AmeenCollege of Pharmacy Bangalore
  • Parashwar Gogoi Department of Pharmacology Al-AmeenCollege of Pharmacy Bangalore
  • Yojana Khariwara Department of Pharmacology Al-Ameen College of Pharmacy Bangalore

Abstract

The exponential growth of the human population in a growing nation like India is one of its most serious issues. Contraceptives that are readily available and acceptable are required in many poorer countries to reduce population growth and in all countries to prevent maternal morbidity and mortality arising from unintended pregnancies. Worldwide, women consume contraceptives at a rate of about 90%. Commercially available birth control tablets are deleterious to women's health and occasionally death. Such pills can lead to fat deposition in the liver, kidneys, and uterus, a rupture of the uterus epithelial layer, irregular and unpleasant menstruation, breast cancer, and finally irreversible infertility. They can also impede metabolism and subsequent pregnancy. When considering the treatment of illnesses that often aren't treatable by allopathic medicine, the term "herbal plants" became a prevalent one that entered everyone's consciousness. Ancient physicians were cognizant of plants that may be used as contraceptives. Herbs with an anti-fertility effect include herbal contraceptives. Although less effective than pills, herbal contraceptives can be used as a less harmful option. Modern research on contraception has recently turned its attention to the study of natural herbal contraception.

Keywords: Contraception, Infertility, Anti-fertility, menstruation

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References

1. Solakhia R, Gupta J, Parashar B. Herbal Contraceptives: Anti-fertility Activity of Herbal Plants. International Journal of Health and Clinical Research. 2019;2(4):5-10.
2. Bhakta S, Das SK. Baleful Effects of the Commercial Birth Control Pills and Focus on Frontier Herbal Contraceptives Devoid of Side Effects.
3. Daniyal M, Akram M. Antifertility activity of medicinal plants. Journal of the Chinese Medical Association. 2015 Jul 1;78(7):382-8.
4. Kaur R, Sharma A, Kumar R, Kharb R. Rising trends towards herbal contraceptives. J Nat Prod Plant Resour. 2011;1(4):5-12.
5. Pal r, Mukherjee a, Saha a. Exploring post-coital anti-fertility activity with toxicological and hormonal profiling of Sapindustrifoliatuslinn. International research journal of pharmaceutical and applied sciences. 2013 oct 31;3(5):53-60.
6. Thanamool C, Thaeomor A, Chanlun S, Papirom P, Kupittayanant S. Evaluating the anti-fertility activity of Talinum paniculatum (Jacq.)Gaertnin female Wistar rats. Aust. J. Plant Physiol. 2013;7:1802-7.
7. Singh, A., Srinivasan, A.K., Chakrapani, L.N. and Kalaiselvi, P., 2019. LOX-1, the common therapeutic target in hypercholesterolemia: a new perspective of antiatherosclerotic action of aegeline. Oxidative medicine and cellular longevity, 2019.
8. Das B, Dey A, Talukdar AD, Nongalleima K, Choudhury MD, Deb L. Antifertility efficacy of Drynariaquercifolia (L.) J. Smith on female Wister albino rats. Journal of Ethnopharmacology. 2014 Apr 28;153(2):424-9.
9. Shaik A, Kanhere RS, Cuddapah R, Nelson KS, Vara PR, Sibyala S. Antifertility activity of Artemisia vulgaris leaves on female Wistar rats. Chinese Journal of NaturalMedicine. 2014 Mar 1;12(3):180-5.
10. Mziray AM, Maina CI, Kaingu CK. Anti-fertility properties of Cissus rotundifolia (Forssk.) Vahl. Extract using female Wistar rats. Discovery Phytomedicine. 2020;7(2):58-64.
11. Singh, A., Gowtham, S., Chakrapani, L.N., Ashokkumar, S., Kumar, S.K., Prema, V., Bhavani, R.D., Mohan, T. and Sathyamoorthy, Y.K., 2018. Aegeline vs Statin in the treatment of Hypercholesterolemia: A comprehensive Soni P, Siddiqui AA, Dwivedi J, Soni V. Anti-ovulatory and estrogenic activity of leaves of Datura stramonium Linn. in female albino rats. Asian Journal of Pharmaceutical Research and Health Care. 2013;5(2):65-71.
12. Malpani A, Mahurkar N, Aswar U. Phytochemical analysis and antifertility potential of Cynodondactylon in female Wistar rats: A herbal approach towards contraception. Chinese Herbal Medicines. 2020 Jul 1;12(3):281-8.
13. Rabadia JP, Desai TR, Thite VS. The pharmacological evaluation of the antifertility role of Plumeria acuminata on the reproduction of female Wistar rats. Journal of Applied Pharmaceutical Science. 2022 Aug 4;12(8):202-13.
14. Alhaj WT, Moharram BA, Al-Maqtari T, Al-Mahbashi HM, Al-Doaiss AA. The potential of jatropha variegata fruits as a natural contraceptive: Antifertility activity and phytochemical analysis. Evidence-Based Complementary and Alternative Medicine. 2022 Feb 21;2022.
15. Idu M, Ogedegbe-George S, Oriarewo PE, Gabriel BO. Spermicidal, Antifertility and Contraceptive Effect of Azadirachta indica A. Juss. Seed Extract in Female and Male Wistar Rats. Biology, Medicine, & Natural Product Chemistry. 2023;12(1):79-88.
16. Singh, A., Kumar, A. and Kalaiselvi, P., 2018. Aegeline, targets LOX1, the receptor for oxidized LDL to mitigate hypercholesterolemia: a new perspective in its anti-atherosclerotic action. Free Radical Biology and Medicine, 128, p.S41.
17. Memudu AE, Oluwole TJ. The contraceptive potential of Carica papaya seed on oestrus cycle, progesterone, and histomorphology of the Utero-ovarian tissue of adult Wistar rats. JBRA Assisted Reproduction. 2021 Jan;25(1):34.
18. Singh, A., 2022. Role of microbial metabolites in cardiovascular and human health. In Microbiome, Immunity, Digestive Health and Nutrition (pp. 137-148). Academic Press.
19. Zargar HB. Antifertility activity of ethanolic and aqueous extracts of Crocus Sativus (Saffron) on female rats. International Journal of Research and Analytical Reviews. 2020;7(4):877-82.
20. Sharma RK, Goyal AK, Yadav SK, Bhat RA. Anti-fertility activity of Ficus religiosa fruits extracts on goat uterus in vitro. Int J Drug Dev and Res. 2013;5(4):330-5.
21. Singh, A., 2022. Hyperlipidemia in cardiovascular health and digestion. In Nutrition and Functional Foods in Boosting Digestion, Metabolism and Immune Health (pp. 141-150). Academic Press.
22. Singh R, Kakar S, Shah M, Jain R. Some medicinal plants with anti-fertility potential: a current status. Journal of Basic and clinical reproductive sciences. 2018;7(1).
23. Mali S, Bendre S, Patil S. Overview of Pharmacognostical and Pharmacological properties of Moringa oleifera. Asian Journal of Pharmacy and Technology. 2022;12(1):77-83.
24. Soni P, Siddiqui AA, Dwivedi J, Soni V. Anti-ovulatory and estrogenic activity of stem of Musa paradisiaca in female albino rats. Journal of Applied Pharmaceutical Science. 2013 Aug 30;3(8):102-6.
25. Roh, J., Hill, J.A., Singh, A.,Valero-Muñoz, M. and Sam, F., 2022. Heart failure with preserved ejection fraction: heterogeneous syndrome, diverse preclinical models. Circulation Research, 130(12), pp.1906-1925.
26. Shah SK, Jhade DN. Evaluation of the antifertility potential of Piper betle (Petiole) on female wistar rats “rising approaches of herbal contraception’’. Biochemistry and Biophysics Reports. 2018 Sep 1;15:97-102.
27. Singh R, Kakar S, Shah M, Jain R. Some medicinal plants with anti-fertility potential: a current status. Journal of Basic and clinical reproductive sciences. 2018;7(1).
28. Shiv Chandra Singh, A., Yu, A., Chang, B., Li, H., Rosenzweig, A. and Roh, J.D., 2021. Exercise Training Attenuates Activin Type II Receptor Signaling in the Aged Heart. Circulation, 144(Suppl_1), pp.A14259-A14259.
29. Soni PK, Luhadia G, Sharma DK, Mali PC. Antifertility activates of traditional medicinal plants in males with emphasis on their mode action: a review. Journal of Global Biosciences. 2015;4(1):1165-79.
30. Soni PK, Mali PC. Oral administration of petroleum ether extract of Tecomellaundulata leaves affects spermatogenesis and fertility of male rats. Europ J Biomed Pharmaceut Sci. 2016;3:339-44.
31. Boini, K.M., singh, A. and Koka, S.S., 2021. Gut Microbial Metabolite Trimethylamine N-oxide Enhances Endoplasmic Reticular Stress and Promotes Endothelial Dysfunction. Circulation, 144(Suppl_1), pp.A14071-A14071.
32. Bhatt N, Deshpande M. A critical review and scientific perspective on contraceptive therapeutics from Ayurveda and allied ancient knowledge. Frontiers in pharmacology. 2021 Jun 3;12:629591.
Published
29/08/2023
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How to Cite
[1]
D. Priya, “Indigenous plants as Oral Herbal Contraceptive: an Updated Review”, Int J Indig Herb Drug, vol. 8, no. 4, pp. 14-19, Aug. 2023.
Section
Review Articles